Founded in 1936, the Mint Museum Randolph was the first art museum in the state of North Carolina. Housed in the building that once contained the United States mint, the art museum now provides guests and visitors with access to a vast collection of tens of thousands of pieces of artwork. There are two branches of the Mint Museum: Mint Museum Randolph, and Mint Museum Uptown. Both showcase different permanent and visiting collections and exhibitions.

Rosedale Plantation dates back to 1815 when enslaved persons built the home on behalf of merchant Archibald Frew. Frew owned a small number of slaves and most of his wealth was inherited, leading some in the town to scoff at the grand home and vast plantation. After falling into debt, Archibald Frew was aided by his sister's husband William Davidson who purchased the property and allowed Frew to stay on the property until his death in 1824. In 1827, physician David Caldwell, the husband of Frew's niece Harriet purchased the estate. The Caldwells owned thirty enslaved persons, including Cherry who raised the Caldwell children after Harriet passed away. While the Caldwell family sold most of the 900 acres, they kept the home in the family until the 1980s. The Colonial Dames assisted the Historic Rosedale Foundation who acquired the property when it went on the market in 1987. Thanks to their efforts, the home, and the remaining eight-and-a-half acres serve as a historical house museum, feating original furnishings and artifacts from previous owners and offering information and education on select aspects of antebellum architecture and history.

Spanning an area greater than thirty city blocks, the historic Fourth Ward offers a blend of Victorian homes, modern day condos, shops, and thick, tree lined streets that offer visitors and residents a view of Charlotte’s historic past. Accessible via a walking tour, the path leads past many of Charlotte’s oldest and most historically significant buildings. The Friends of the Fourth Ward Organization and the city of Charlotte have developed literature to educate visitors of the historical significance of many of the buildings. Maps and literature can be picked up at INFO! Charlotte, the visitor center, located at 501 S College St, several blocks from the Fourth Ward, or online.

Built in 1914, the Latta Arcade is surrounded by modern office buildings and is one of the last remaining buildings from the early 20th century in this part of downtown Charlotte. The building has been listed on the National Register of Historic Places and holds a gallery of shops, restaurants, and offices.

This museum is located within the Wells Fargo Center, the 7th tallest skyscraper in Charlotte. The building houses the professional offices of Wells Fargo and other companies, but for visitors to the city, the building is most significant as the home of the Charlotte branch of the Wells Fargo History Museum. This interactive and educational museum illustrates the company’s growth from servicing 1850’s pioneers to becoming one of the nation’s top financial institutions. The museum exhibits educate guests about the history of money and banking as well as the role of the Wells Fargo company within the nation's economy.

Although it was officially incorporated in the state of North Carolina in 1991, the Levine Museum of the New South didn't officially open its doors at the state-of-the-art 200 East Seventh Street location until 2001. With 40,000 square feet of exhibit space, this interactive museum houses the nation's most comprehensive interpretation of post-Civil War Southern history. The permanent exhibit, Cotton Fields to Skyscrapers: Reinventing Charlotte and the Carolina Piedmont in the New South, traces the history of the region from the end of the Civil War to the present, using a number of interactive tools. Seasonal and special exhibits complete the experience and focus on certain aspects of Southern culture and history. The Levine Museum of the New South has won numerous awards, including the National Award for Museum and Library Service.

The Duke Mansion is one of the largest and most striking homes in Charlotte. As its name indicates, it was once the home of tobacco magnate James Buchanan "Buck" Duke. The home is listed on the National Register of Historic Places.

The Bechtler Museum of Modern Art houses a unique and rare collection of 20th-century modern pieces of artwork. Amassed by a North Carolina resident family and donated to the museum, the permanent and rotating exhibits demonstrate significant contributions to art from this time period.The museum building itself is unique, created by a well known Swiss architect, and designed specifically to showcase the pieces of work. The Betchtler Museum is visited by thousands of art enthusiasts each year who are welcome to view the collection and rotating exhibits. Distinguishing itself from Charlotte's other Uptown museums, The Bechtler is Charlotte’s boutique cultural space. The distinct red terracotta tiled building was designed by internationally acclaimed architect Mario Botta and opened in 2010. This jewel of a museum houses the personal collection of the Swiss industrialist family, The Bechtlers. Found in the museum are works by the most important and influential artists of the mid-20th century including Miro, Giacometti, Picasso, Calder and Warhol.

Discovery Place has interactive exhibits for children of all ages and adults. The complex includes an IMAX Theater as well as several other theaters and several floors of interactive exhibits along with shows about everything from dinosaurs to the science of fire. There are play areas for the youngest children and even some exhibits that adults will love. For example, guests will encounter organisms and creatures from across the globe in World Alive, an exhibit that includes learning laboratories as well as an aquarium and rainforest.