The Museum of Arts and Design (MAD) first opened its doors in 1956 as the Museum of Contemporary Crafts, with an original mission of recognizing the craftsmanship of contemporary American artists. The museum was founded by Aileen Osborn Webb, a patron of the arts. Today, the museum fosters the creative process and how it influences crafted works that better our contemporary lives. This is accomplished by educating and inspiring the public through exhibitions, family programs, workshops, and classes. The museum also includes a restaurant and theatre to provide visitors with an all-day experience.

The Asia Society Museum was one of the first American museums to establish a program of contemporary Asian art. The Society was founded by John D. Rockefeller 3rd in 1956. The goal of the Society is to foster an understanding between peoples, leaders, and institutions in Asia and the United States. The Museum uses art and culture to encourage a global understanding of one another in order to ensure a shared future. The Museum holds tours, rotating exhibitions, and family events for visitors to enjoy.

The Chrysler Building is an Art Deco-style skyscraper located in the Turtle Bay neighborhood of Midtown Manhattan and was the former headquarters of the Chrysler Corporation. Designed by William Van Alen, it stands at a towering 1,046 feet tall and was the world's tallest building before being surpassed by the iconic Empire State Building in April 1931. It is the tallest brick building in the world, although it contains a steel frame. When Walter Chrysler commissioned the building, he dedicated it to "world commerce and industry."

Designed by architect William Burnet Tuthill and built by philanthropist Andrew Carnegie in 1891, Carnegie Hall remains among the most famous and prestigious venues in the world for both classical music and popular music. Carnegie Hall has its own artistic programming, development, and marketing departments and presents about 250 performances each year. Visitors can tour the building and also visit the Rose Museum which preserves and presents the history of the venue.

Barton Academy was named for Willoughby Barton, an Alabama state legislator from Mobile. Barton introduced an act that created the Board of School Commissioners of Mobile County on January 10, 1826 which was the first education board in Alabama. This school was completed in 1836 and is the oldest public school building in the state of Alabama. The building is presently on the state's list of threatened historical landmarks due to its condition and the funds required to preserve the historic building.

The original Battle House Hotel was opened by James Battle and his two half-nephews, John and Samuel, in 1852. The original building burned down in 1905 and was replaced by the construction of this building in 1908. It is currently called the Battle House Renaissance Mobile Hotel and Spa.

This three-story brick and plaster Greek Revival style hospital is one of the oldest hospitals in Mobile. The cornerstone for the building was laid in 1830 and was dedicated after completion of the building in 1831. The building served as a hospital for over a hundred years from 1831 to July of 1966, seeing the city through multiple rounds of yellow fever and the Civil War. Between 1839 and 1897 Mobile was plagued with recurring epidemics of yellow fever, those afflicted were often cared for here. In 1873, 40% of those who were treated for yellow fever at the City Hospital died. In 1897 yellow fever’s last year in Mobile, 35 of the 300 afflicted by yellow fever perished. During the tail end of the Civil War, the building was occupied by Confederate Soldiers and was used as a medical facility during the Battle of Mobile Bay in August 1864. In 1854 the Daughters of Charity began practicing nursing in the hospital and by 1861 had taken over the administration of the hospital. The sisters continued to run the facility until April 15, 1959. Not long after, the hospital was closed in July 1966 when patients were admitted to the newer city hospital. The hospital was given a historical marker in 1964 and on February 26th, 1970 the building was added to the National Register of Historic Places. Today the building serves as office space for Mobile businesses.

The Mobile chapter of the International Longshoreman’s Association (ILA) Hall was established in 1936 to represent African Americans working on the city's docks. Dr. Martin Luther King, Jr. spoke here on January 1, 1959.

Beauvoir was the last home of Jefferson Davis and it was the site of his retirement. A National Historic Landmark, the complex includes the Jefferson Davis Presidential Library, the restored antebellum home, the Confederate Museum and veteran's cemetery on 51 landscaped acres fronting the Gulf of Mexico. Beauvoir, the Jefferson Davis Home and Presidential Library, is owned and operated by the Mississippi Division Sons of Confederate Veterans.

Located on the Eastern tip of the Biloxi peninsula, the Maritime and Seafood Industry Museum is housed in a Spanish influence structure built in 1934 as part of a U.S. Coast Guard station. The museum was established in 1986 to preserve and interpret the maritime history and heritage of biloxi and the Mississippi gulf coast. It accomplishes this mission through an array of exhibits containing historic photographs and objects. Visitors can experience the tremendous impact of hurricanes on biloxi through an exhibit and film on hurricane Camille, which devastated the Gulf Coast in 1969. the museum has brought biloxi’s maritime history to life by replicating two full-size Biloxi schooners, which sail the Gulf waters daily.